PPM1D Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. Belongs to the PP2C family. Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11 C|11 51.34 cM
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  catalytic activity; cation binding; hydrolase activity; magnesium-dependent protein serine/threonine phosphatase activity; metal ion binding; mitogen-activated protein kinase binding; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity
Biological Process:  cell cycle; chromatin silencing; DNA damage response, signal transduction by p53 class mediator; DNA methylation; G2/M transition of mitotic cell cycle; negative regulation of gene expression, epigenetic; peptidyl-threonine dephosphorylation; protein dephosphorylation; response to bacterium
Reference #:  Q9QZ67 (UniProtKB)
Alt. Names/Synonyms: AV338790; OTTMUSP00000000998; p53-induced protein phosphatase 1; PP2C-delta; Ppm1d; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; Wip1
Gene Symbols: Ppm1d
Molecular weight: 65,723 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA