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USP9X
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration. Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity. Belongs to the peptidase C19 family. Widely expressed in embryonic and adult tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: Xp11.4 |
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Cellular Component:
cilium; cytoplasm; cytoskeleton; cytosol; growth cone; nucleus
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Molecular Function:
co-SMAD binding; cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; deubiquitinase activity; K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; protein binding
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Biological Process:
amyloid fibril formation; axon extension; BMP signaling pathway; cell division; cell migration; chromosome segregation; female gamete generation; monoubiquitinated protein deubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of transcription by RNA polymerase II; neuron migration; positive regulation of DNA demethylation; positive regulation of protein binding; positive regulation of TORC2 signaling; protein deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; protein import into peroxisome matrix, receptor recycling; protein K63-linked deubiquitination; protein localization; protein stabilization; protein ubiquitination; regulation of circadian rhythm; rhythmic process; transforming growth factor beta receptor signaling pathway
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Disease: Mental Retardation, X-linked 99; Mental Retardation, X-linked 99, Syndromic, Female-restricted
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Reference #:
Q93008
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related, X-linked; FAF; FAM; Fat facets in mammals; fat facets protein related, X-linked; Fat facets protein-related, X-linked; hFAM; MRX99; MRXS99F; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin specific peptidase 9 X-linked; ubiquitin specific peptidase 9, X-linked; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); Ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X; USP9; USP9X
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Gene Symbols: USP9X
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Molecular weight:
290,463 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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