USP9X Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration. Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity. Belongs to the peptidase C19 family. Widely expressed in embryonic and adult tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component:  cytoplasm; cytosol; growth cone
Molecular Function:  co-SMAD binding; cysteine-type peptidase activity; Lys48-specific deubiquitinase activity; protein binding; thiol-dependent ubiquitinyl hydrolase activity; ubiquitinyl hydrolase activity
Biological Process:  axon extension; BMP signaling pathway; cell cycle; cell division; cellular protein metabolic process; chromosome segregation; female gamete generation; negative regulation of transcription by RNA polymerase II; neuron migration; positive regulation of DNA demethylation; protein deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; protein K48-linked deubiquitination; protein stabilization; protein targeting to peroxisome; protein ubiquitination; regulation of circadian rhythm; rhythmic process; transforming growth factor beta receptor signaling pathway
Disease: Mental Retardation, X-linked 99; Mental Retardation, X-linked 99, Syndromic, Female-restricted
Reference #:  Q93008 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme FAF-X; DFFRX; Drosophila fat facets related, X-linked; FAF; FAM; Fat facets in mammals; fat facets protein related, X-linked; Fat facets protein-related, X-linked; hFAM; MRX99; MRXS99F; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin specific peptidase 9 X-linked; ubiquitin specific peptidase 9, X-linked; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); Ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X; USP9; USP9X
Gene Symbols: USP9X
Molecular weight: 290,463 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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