FANCG DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Highly expressed in testis and thymus. Found in lymphoblasts. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  cytosol; Fanconi anaemia nuclear complex; mitochondrion; nucleolus; nucleoplasm; plasma membrane
Molecular Function:  damaged DNA binding; protein binding
Biological Process:  DNA repair; interstrand cross-link repair; mitochondrion organization; ovarian follicle development; response to radiation; spermatid development
Disease: Fanconi Anemia, Complementation Group G
Reference #:  O15287 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC9; FA complementation group G; FAG; FANCG; Fanconi anemia complementation group G; Fanconi anemia group G protein; Fanconi anemia, complementation group G; Protein FACG; truncated Fanconi anemia group G protein; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9
Gene Symbols: FANCG
Molecular weight: 68,554 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

FANCG

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene