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FANCG
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Highly expressed in testis and thymus. Found in lymphoblasts. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of human Ortholog: 9p13.3 |
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Cellular Component:
chromatin; cytosol; Fanconi anaemia nuclear complex; mitochondrion; nucleolus; nucleoplasm; plasma membrane
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Molecular Function:
damaged DNA binding; protein binding
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Biological Process:
DNA damage response; DNA repair; interstrand cross-link repair; mitochondrion organization; ovarian follicle development; protein monoubiquitination; response to radiation; spermatid development
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Disease: Fanconi Anemia, Complementation Group G
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Reference #:
O15287
(UniProtKB)
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Alt. Names/Synonyms: DNA repair protein XRCC9; FA complementation group G; FAG; FANCG; Fanconi anemia complementation group G; Fanconi anemia group G protein; Fanconi anemia, complementation group G; Protein FACG; truncated Fanconi anemia group G protein; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9
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Gene Symbols: FANCG
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Molecular weight:
68,554 Da
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Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
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