NSF
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle |
Chromosomal Location of human Ortholog: 17q21.31 |
Cellular Component:
cytosol; dendritic shaft; Golgi apparatus; Golgi stack; plasma membrane; postsynaptic density
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent protein disaggregase activity; ionotropic glutamate receptor binding; metal ion binding; PDZ domain binding; protein binding; protein kinase binding; protein-containing complex binding; SNARE binding; syntaxin-1 binding
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Biological Process:
exocytosis; Golgi to plasma membrane protein transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; plasma membrane fusion; positive regulation of protein catabolic process; positive regulation of receptor recycling; potassium ion transport; regulation of exocytosis; SNARE complex disassembly; vesicle-mediated transport
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Disease: Developmental And Epileptic Encephalopathy 96
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Reference #:
P46459
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; N-ethylmaleimide sensitive factor, vesicle fusing ATPase; N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive factor-like protein; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; NSF; SEC18; SKD2; Vesicle-fusing ATPase; Vesicular-fusion protein NSF
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Gene Symbols: NSF
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Molecular weight:
82,594 Da
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Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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