Kv7.3 Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 8q24.22
Cellular Component:  axon initial segment; cell surface; integral component of plasma membrane; node of Ranvier; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  calmodulin binding; protein binding; voltage-gated potassium channel activity
Biological Process:  chemical synaptic transmission; membrane hyperpolarization; potassium ion transmembrane transport; regulation of ion transmembrane transport
Disease: Seizures, Benign Familial Neonatal, 2
Reference #:  O43525 (UniProtKB)
Alt. Names/Synonyms: BFNC2; EBN2; KCNQ3; KQT-like 3; KV7.3; Potassium channel subunit alpha KvLQT3; potassium channel, voltage gated KQT-like subfamily Q, member 3; potassium channel, voltage-gated, subfamily Q, member 3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel subfamily Q member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; Voltage-gated potassium channel subunit Kv7.3
Gene Symbols: KCNQ3
Molecular weight: 96,742 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein