Kv7.3 Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  axon initial segment; cell surface; dendrite; integral component of membrane; integral component of plasma membrane; membrane raft; neuron projection; neuronal cell body; node of Ranvier; plasma membrane; somatodendritic compartment; voltage-gated potassium channel complex
Molecular Function:  calmodulin binding; delayed rectifier potassium channel activity; ion channel binding; potassium channel activity; protein kinase binding; ubiquitin protein ligase binding; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  cellular response to ammonium ion; ganglion development; ion transmembrane transport; membrane hyperpolarization; oligodendrocyte development; potassium ion transmembrane transport; regulation of ion transmembrane transport
Reference #:  O88944 (UniProtKB)
Alt. Names/Synonyms: Kcnq3; KQT-like 3; Kv7.3; Potassium channel subunit alpha KvLQT3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; Voltage-gated potassium channel subunit Kv7.3
Gene Symbols: Kcnq3
Molecular weight: 96,898 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene