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Kv7.3
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: 7q34 |
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Cellular Component:
axon initial segment; cell surface; dendrite; mitochondrion; neuronal cell body; node of Ranvier; plasma membrane; somatodendritic compartment; synapse; voltage-gated potassium channel complex
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Molecular Function:
calmodulin binding; potassium channel activity; protein kinase binding; transmembrane transporter binding; ubiquitin protein ligase binding; voltage-gated monoatomic ion channel activity; voltage-gated potassium channel activity
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Biological Process:
action potential initiation; apoptosome assembly; cellular response to ammonium ion; cellular response to calcium ion; cellular response to xenobiotic stimulus; establishment of localization in cell; excitatory chemical synaptic transmission; ganglion development; gene expression; inhibitory chemical synaptic transmission; membrane hyperpolarization; mitochondrial depolarization; monoatomic ion transmembrane transport; nerve development; neuron apoptotic process; neuron remodeling; neuronal action potential; oligodendrocyte development; potassium ion transmembrane transport; protein import into nucleus; protein targeting; protein transport; protein-containing complex assembly; psychomotor behavior; regulation of action potential firing threshold; regulation of monoatomic ion transmembrane transport; regulation of synaptic plasticity; response to auditory stimulus; response to mechanical stimulus; response to organic cyclic compound; sensory perception of sound; substantia propria of cornea development
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Reference #:
O88944
(UniProtKB)
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Alt. Names/Synonyms: Kcnq3; KQT-like 3; Kv7.3; Potassium channel subunit alpha KvLQT3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; Voltage-gated potassium channel subunit Kv7.3
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Gene Symbols: Kcnq3
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Molecular weight:
96,898 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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