MEK2 Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; MAPK cascade; peptidyl-tyrosine phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q90891 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MKK2; MP2K2; PRKMK2
Gene Symbols: MAP2K2
Molecular weight: 44,078 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
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MEK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein