Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: cytoplasm
Molecular Function: ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process: activation of MAPK activity; activation of protein kinase activity; MAPK cascade; peptidyl-tyrosine phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade