| MEK2 Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB. |
| Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family |
| Cellular Component: cytoplasm |
| Molecular Function: ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity |
| Biological Process: activation of MAPK activity; activation of protein kinase activity; MAPK cascade; peptidyl-tyrosine phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade |
| Reference #: Q90891 (UniProtKB) |
| Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MKK2; MP2K2; PRKMK2 |
| Gene Symbols: MAP2K2 |
| Molecular weight: 44,078 Da |
| Basal Isoelectric point: 6.24 Predict pI for various phosphorylation states |
| CST Pathways: Actin Dynamics | Angiogenesis | B Cell Receptor Signaling | ErbB/HER Signaling | ESC Pluripotency and Differentiation | GPCR Signaling to MAPKs | Growth And Differentiation Control by MAPKs | IL6 Signaling | Insulin Receptor Signaling | T Cell Receptor Signaling | Warburg Effect |
| Select Structure to View Below |
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MEK2 |
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| Cross-references to other databases: STRING | Pfam | ENZYME | Phospho.ELM | UniProtKB | Entrez-Gene | GenPept | Ensembl Gene | Ensembl Protein |