CRY1 Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Binds MAPK. Interacts with FBXL21. Interacts with FBXL3. Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the autoregulatory feedback loop. Belongs to the DNA photolyase class-1 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Lyase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q23.3
Cellular Component:  mitochondrion; nucleus
Molecular Function:  blue light photoreceptor activity; DNA binding; double-stranded DNA binding; E-box binding; histone deacetylase binding; nuclear hormone receptor binding; nucleotide binding; phosphatase binding; protein binding; protein kinase binding
Biological Process:  blue light signaling pathway; circadian regulation of gene expression; circadian rhythm; DNA damage induced protein phosphorylation; entrainment of circadian clock by photoperiod; gluconeogenesis; glucose homeostasis; lipid storage; negative regulation of circadian rhythm; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of glucocorticoid secretion; negative regulation of gluconeogenesis; negative regulation of protein ubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of protein ubiquitination; protein-chromophore linkage; regulation of circadian rhythm; regulation of DNA damage checkpoint; response to activity; response to glucagon; response to insulin; response to light stimulus
Disease: Delayed Sleep Phase Syndrome, Susceptibility To
Reference #:  Q16526 (UniProtKB)
Alt. Names/Synonyms: CRY1; cryptochrome 1 (photolyase-like); Cryptochrome-1; PHLL1
Gene Symbols: CRY1
Molecular weight: 66,395 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene