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mGluR1
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Belongs to the G-protein coupled receptor 3 family. Detected in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of rat Ortholog: 1p13 |
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Cellular Component:
apical plasma membrane; axon; collagen-containing extracellular matrix; dendrite; dendritic spine; G protein-coupled receptor dimeric complex; G protein-coupled receptor homodimeric complex; glutamatergic synapse; neuron projection; nucleus; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; collagen binding; fibronectin binding; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; G protein-coupled receptor activity; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; laminin binding; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; nuclear estrogen receptor binding; PLC activating G protein-coupled glutamate receptor activity; protein binding; protein sequestering activity
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; cellular response to electrical stimulus; chemical synaptic transmission; chemical synaptic transmission, postsynaptic; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; L-glutamate import across plasma membrane; locomotory behavior; membrane depolarization; negative regulation of protein localization to plasma membrane; negative regulation of viral entry into host cell; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of MAPK cascade; receptor-mediated virion attachment to host cell; regulation of glutamate secretion; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of sensory perception of pain; regulation of synaptic transmission, glutamatergic; sensory perception of pain; synaptic transmission, GABAergic
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Reference #:
P23385
(UniProtKB)
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Alt. Names/Synonyms: G protein coupled receptor family C group 1 member A; glutamate receptor, metabotropic 1; Gprc1a; Grm1; Metabotropic glutamate receptor 1; Mglur1
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Gene Symbols: Grm1
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Molecular weight:
133,236 Da
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Basal Isoelectric point:
6.48
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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