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PSD-93 iso9
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Belongs to the MAGUK family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 7 E1|7 51.07 cM |
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Cellular Component:
axon initial segment; basolateral plasma membrane; cell junction; cell projection; dendrite; glutamatergic synapse; juxtaparanode region of axon; membrane; neuromuscular junction; neuron projection; neuronal cell body; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synapse; synaptic vesicle membrane
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Molecular Function:
kinase binding; PDZ domain binding; protein binding; protein phosphatase binding; protein-containing complex binding; structural constituent of postsynaptic density
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Biological Process:
anterograde axonal protein transport; cell-cell adhesion; cellular response to potassium ion; chemical synaptic transmission; clustering of voltage-gated potassium channels; embryo development; establishment or maintenance of epithelial cell apical/basal polarity; neuronal ion channel clustering; neurotransmitter receptor localization to postsynaptic specialization membrane; receptor clustering; receptor localization to synapse; retrograde axonal protein transport; sensory perception of pain
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Reference #:
BAC32772
(GenPept)
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Alt. Names/Synonyms: A330103J02Rik; B330007M19Rik; channel-associated protein of synapse-110; chapsyn-110; discs large homolog 2; discs large MAGUK scaffold protein 2; discs, large homolog 2 (Drosophila); disks large homolog 2; Dlg2; Dlgh2; Gm1197; OTTMUSP00000018435; postsynaptic density protein PSD-93; PSD-93 iso9; PSD93
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Gene Symbols: Dlg2
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Molecular weight:
53,600 Da
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Basal Isoelectric point:
6.93
Predict pI for various phosphorylation states
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