ARFGEF1 Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. Expressed in placenta, lung, heart, brain, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, ARF; Nucleolus
Chromosomal Location of human Ortholog: 8q13.2
Cellular Component:  cytosol; Golgi apparatus; Golgi membrane; nuclear matrix; nucleolus; nucleoplasm; perinuclear region of cytoplasm; small nuclear ribonucleoprotein complex; trans-Golgi network
Molecular Function:  guanyl-nucleotide exchange factor activity; myosin binding; protein binding; protein kinase A regulatory subunit binding
Biological Process:  endomembrane system organization; exocytosis; Golgi organization; negative regulation of actin filament polymerization; negative regulation of GTPase activity; neuron projection development; positive regulation of GTPase activity; positive regulation of protein glycosylation in Golgi; positive regulation of protein kinase B signaling; positive regulation of wound healing; protein transport; regulation of ARF protein signal transduction; regulation of establishment of cell polarity
Reference #:  Q9Y6D6 (UniProtKB)
Alt. Names/Synonyms: ADP ribosylation factor guanine nucleotide exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); ARFGEF1; ARFGEP1; BIG1; Brefeldin A-inhibited GEP 1; Brefeldin A-inhibited guanine nucleotide-exchange protein 1; D730028O18Rik; DKFZP434L057; P200; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1
Gene Symbols: ARFGEF1
Molecular weight: 208,767 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene