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HIVEP1
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding |
| Chromosomal Location of Human Ortholog: 13 A4|13 20.72 cM |
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Cellular Component:
mitochondrion; nuclear body; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding; metal ion binding; nucleic acid binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; zinc ion binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
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Reference #:
Q03172
(UniProtKB)
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Alt. Names/Synonyms: Alpha A-CRYBP1; Alpha A-crystallin-binding protein 1; Alpha A-crystallin-binding protein I; alphaA-CRYBP1; Cryabp1; crystallin, alpha binding protein 1; HIV type I enhancer binding protein 1; Hivep1; human immunodeficiency virus type I enhancer binding protein 1; human immunodeficiency virus type I enhancer-binding protein 1; Transcription factor alphaA-CRYBP1; ZEP1; Zinc finger protein 40; Znf40
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Gene Symbols: Hivep1
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Molecular weight:
288,344 Da
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Basal Isoelectric point:
7.56
Predict pI for various phosphorylation states
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