HIVEP1 This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 13 A4|13 20.72 cM
Cellular Component:  mitochondrion; nuclear body; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding; metal ion binding; nucleic acid binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; zinc ion binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q03172 (UniProtKB)
Alt. Names/Synonyms: Alpha A-CRYBP1; Alpha A-crystallin-binding protein 1; Alpha A-crystallin-binding protein I; alphaA-CRYBP1; Cryabp1; crystallin, alpha binding protein 1; HIV type I enhancer binding protein 1; Hivep1; human immunodeficiency virus type I enhancer binding protein 1; human immunodeficiency virus type I enhancer-binding protein 1; Transcription factor alphaA-CRYBP1; ZEP1; Zinc finger protein 40; Znf40
Gene Symbols: Hivep1
Molecular weight: 288,344 Da
Basal Isoelectric point: 7.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene