Oct1 Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. Belongs to the POU transcription factor family. Class-2 subfamily. Ubiquitous. Isoform 2 is lymphocyte-specific. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 1 H2.3|1 73.21 cM
Cellular Component:  endoplasmic reticulum; intracellular membrane-bounded organelle; nucleoplasm; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  lens induction in camera-type eye; negative regulation of gene expression; negative regulation of transcription, DNA-templated; olfactory placode formation; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P25425 (UniProtKB)
Alt. Names/Synonyms: 2810482H01Rik; NF-A1; Oct; Oct-; Oct-1; Oct1; Octamer-binding protein 1; Octamer-binding transcription factor 1; Otf; Otf-; OTF-1; Otf1; PO2F1; POU domain, class 2, transcription factor 1; Pou2f1; ubiquitous transcription factor
Gene Symbols: Pou2f1
Molecular weight: 79,547 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene