UNG Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.2.27; Hydrolase
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  mitochondrion; nucleoplasm; nucleus
Molecular Function:  damaged DNA binding; hydrolase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; ribosomal small subunit binding; uracil DNA N-glycosylase activity; uridine nucleosidase activity
Biological Process:  base-excision repair; base-excision repair, AP site formation via deaminated base removal; cellular response to DNA damage stimulus; DNA repair; isotype switching; negative regulation of apoptotic process; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments
Reference #:  P97931 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000014673; OTTMUSP00000014674; UDG; Ung; Ung1; UNG2; uracil DNA glycosylase; Uracil-DNA glycosylase; uracil-DNA glycosylase nuclear isoform
Gene Symbols: Ung
Molecular weight: 33,926 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
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UNG

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene