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UNG
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.2.2.27; Hydrolase |
| Chromosomal Location of Human Ortholog: 5|5 F |
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Cellular Component:
mitochondrion; nucleoplasm; nucleus
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Molecular Function:
damaged DNA binding; hydrolase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; ribosomal small subunit binding; uracil DNA N-glycosylase activity; uridine nucleosidase activity
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Biological Process:
base-excision repair; base-excision repair, AP site formation via deaminated base removal; cellular response to DNA damage stimulus; DNA repair; isotype switching; negative regulation of apoptotic process; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments
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Reference #:
P97931
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000014673; OTTMUSP00000014674; UDG; Ung; Ung1; UNG2; uracil DNA glycosylase; Uracil-DNA glycosylase; uracil-DNA glycosylase nuclear isoform
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Gene Symbols: Ung
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Molecular weight:
33,926 Da
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Basal Isoelectric point:
9.65
Predict pI for various phosphorylation states
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