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ERR1
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor; Transcription regulation |
| Chromosomal Location of Human Ortholog: 19 A|19 5.08 cM |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding
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Biological Process:
cartilage development; negative regulation of transcription by RNA polymerase II; positive regulation of cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of ossification; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of transcription, DNA-templated
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Reference #:
O08580
(UniProtKB)
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Alt. Names/Synonyms: ERR-alpha; Err1; ERRalpha; Esrra; estrogen receptor related 1; Estrogen receptor-like 1; estrogen related receptor, alpha; Estrogen-related receptor alpha; Estrra; Nr3b1; Nuclear receptor subfamily 3 group B member 1; OTTMUSP00000026942; Steroid hormone receptor ERR1; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
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Gene Symbols: Esrra
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Molecular weight:
45,464 Da
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Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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