ERR1 Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription regulation
Chromosomal Location of mouse Ortholog: 19 A|19 5.08 cM
Cellular Component:  cytoplasm; fibrillar center; intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; nuclear receptor activity; nuclear steroid receptor activity; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; zinc ion binding
Biological Process:  cartilage development; negative regulation of transcription by RNA polymerase II; positive regulation of cellular response to insulin stimulus; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of ossification; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of transcription by RNA polymerase II
Reference #:  O08580 (UniProtKB)
Alt. Names/Synonyms: ERR-alpha; Err1; ERRalpha; Esrra; estrogen receptor related 1; Estrogen receptor-like 1; estrogen related receptor, alpha; Estrogen-related receptor alpha; Estrra; Nr3; Nr3b1; Nuclear receptor subfamily 3 group B member 1; OTTMUSP00000026942; Steroid hormone receptor ERR1; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
Gene Symbols: Esrra
Molecular weight: 45,464 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA