ERG Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Belongs to the ETS family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 16 C4|16 56.04 cM
Cellular Component:  cytoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  cell differentiation; cell migration; endocardial cushion development; endocardial cushion to mesenchymal transition involved in heart valve formation; positive regulation of blood vessel remodeling; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P81270 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastosis virus E-26 (v-ets) oncogene related; D030036I24Rik; Erg; Erg-3; Transcriptional regulator ERG
Gene Symbols: Erg
Molecular weight: 54,614 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene