Ferritin-H Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase
Chromosomal Location of Human Ortholog: 19 A|19 6.23 cM
Cellular Component:  autolysosome; cytoplasm
Molecular Function:  ferric iron binding; ferrous iron binding; ferroxidase activity; identical protein binding; iron ion binding; metal ion binding; oxidoreductase activity
Biological Process:  cellular iron ion homeostasis; intracellular sequestering of iron ion; iron ion transport; negative regulation of fibroblast proliferation; oxidation-reduction process
Reference #:  P09528 (UniProtKB)
Alt. Names/Synonyms: AL022624; AL033366; Ferritin H subunit; Ferritin heavy chain; ferritin heavy chain 1; FHC; FRIH; Fth; Fth1; MFH
Gene Symbols: Fth1
Molecular weight: 21,067 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Ferritin-H

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene