|
lamin A/C
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. Belongs to the intermediate filament family. In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 3 F1|3 38.84 cM |
|
Cellular Component:
intermediate filament; lamin filament; nuclear envelope; nuclear lamina; nuclear matrix; nuclear membrane; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; site of double-strand break
|
|
Molecular Function:
identical protein binding; protein binding; protein phosphatase 1 binding; structural constituent of cytoskeleton
|
|
Biological Process:
cellular senescence; DNA double-strand break attachment to nuclear envelope; establishment of cell polarity; establishment or maintenance of microtubule cytoskeleton polarity; heterochromatin formation; muscle organ development; negative regulation of adipose tissue development; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of mesenchymal cell proliferation; negative regulation of release of cytochrome c from mitochondria; nuclear envelope organization; nuclear migration; nuclear pore localization; nucleus organization; positive regulation of gene expression; positive regulation of osteoblast differentiation; protein import into nucleus; protein localization; protein localization to nuclear envelope; protein localization to nucleus; regulation of cell migration; regulation of protein localization to nucleus; regulation of protein stability; regulation of telomere maintenance; ventricular cardiac muscle cell development
|
|
Reference #:
P48678
(UniProtKB)
|
|
Alt. Names/Synonyms: Dhe; lamin A; lamin A/C; lamin C; Lamin-A/C; Lmn1; Lmna; Prelamin-A/C
|
|
Gene Symbols: Lmna
|
|
Molecular weight:
74,238 Da
|
|
Basal Isoelectric point:
6.54
Predict pI for various phosphorylation states
|
|
CST Pathways:
Death Receptor Signaling
|
PI3K/Akt Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
