UBE4B Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation. Belongs to the ubiquitin conjugation factor E4 family. Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 4 E2|4 79.08 cM
Cellular Component:  cytoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  ATP binding; ATPase binding; enzyme binding; protein binding; ubiquitin protein ligase activity; ubiquitin-ubiquitin ligase activity; unfolded protein binding
Biological Process:  cellular protein catabolic process; granzyme-mediated apoptotic signaling pathway; neuron projection development; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein folding; protein monoubiquitination; protein polyubiquitination; protein ubiquitination; response to endoplasmic reticulum stress; response to UV; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process; ventricular trabecula myocardium morphogenesis
Reference #:  Q9ES00 (UniProtKB)
Alt. Names/Synonyms: 4930551I19Rik; 4933406G05Rik; AU014668; D4Bwg0973e; mKIAA0684; OTTMUSP00000010808; RING-type E3 ubiquitin transferase E4 B; Ube4b; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitination factor E4B; ubiquitination factor E4B, UFD2 homolog; ubiquitination factor E4B, UFD2 homolog (S. cerevisiae); Ufd2; Ufd2a; Ufd2p
Gene Symbols: Ube4b
Molecular weight: 133,318 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene