USP19 Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Belongs to the peptidase C19 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 9|9 F2
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  cysteine-type peptidase activity; Hsp90 protein binding; hydrolase activity; Lys48-specific deubiquitinase activity; metal ion binding; peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; ubiquitin protein ligase binding
Biological Process:  negative regulation of proteasomal protein catabolic process; negative regulation of skeletal muscle tissue development; positive regulation of cell cycle process; protein deubiquitination; protein K48-linked deubiquitination; protein stabilization; proteolysis; regulation of cellular response to hypoxia; regulation of ERAD pathway; regulation of protein stability; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process
Reference #:  Q3UJD6 (UniProtKB)
Alt. Names/Synonyms: 8430421I07Rik; AI047774; Deubiquitinating enzyme 19; Kiaa0891; Ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific peptidase 19; ubiquitin specific protease 19; Ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific processing protease 19; Ubiquitin-specific-processing protease 19; UBP19; Usp19; Zmynd9
Gene Symbols: Usp19
Molecular weight: 150,549 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene