JMJD2B Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of mouse Ortholog: 17|17 D
Cellular Component:  nucleus; pericentric heterochromatin
Molecular Function:  dioxygenase activity; histone demethylase activity; histone H3K36 demethylase activity; histone H3K9 demethylase activity; histone H3K9me2/H3K9me3 demethylase activity; metal ion binding; oxidoreductase activity
Biological Process:  brain development; chromatin organization; chromatin remodeling; histone H3-K36 demethylation; histone H3-K9 demethylation
Reference #:  Q91VY5 (UniProtKB)
Alt. Names/Synonyms: 4732474L06Rik; [histone H3]-trimethyl-L-lysine(9) demethylase 4B; Jhdm3b; JmjC domain-containing histone demethylation protein 3B; Jmjd2b; jumonji domain containing 2B; Jumonji domain-containing protein 2B; Kdm4b; lysine (K)-specific demethylase 4B; Lysine-specific demethylase 4B; MGC6349; mKIAA0876; OTTMUSP00000029076
Gene Symbols: Kdm4b
Molecular weight: 121,604 Da
Basal Isoelectric point: 7.26  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene