JMJD2B
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase |
Chromosomal Location of mouse Ortholog: 17|17 D |
Cellular Component:
chromatin; nucleus; pericentric heterochromatin
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Molecular Function:
dioxygenase activity; histone demethylase activity; histone H3K36 demethylase activity; histone H3K9 demethylase activity; histone H3K9me2/H3K9me3 demethylase activity; metal ion binding; oxidoreductase activity
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Biological Process:
brain development; chromatin organization; chromatin remodeling; regulation of gene expression
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Reference #:
Q91VY5
(UniProtKB)
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Alt. Names/Synonyms: 4732474L06Rik; [histone H3]-trimethyl-L-lysine(9) demethylase 4B; Jhdm3b; JmjC domain-containing histone demethylation protein 3B; Jmjd2b; jumonji domain containing 2B; Jumonji domain-containing protein 2B; Kdm4b; lysine (K)-specific demethylase 4B; Lysine-specific demethylase 4B; MGC6349; mKIAA0876; OTTMUSP00000029076
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Gene Symbols: Kdm4b
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Molecular weight:
121,604 Da
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Basal Isoelectric point:
7.26
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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