CCNK Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). Belongs to the cyclin family. Cyclin C subfamily. Widely expressed. Highest levels in testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of mouse Ortholog: 12 F1|12 59.23 cM
Cellular Component:  cyclin K-CDK12 complex; cyclin K-CDK13 complex; cyclin/CDK positive transcription elongation factor complex; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase binding; RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process:  cell cycle; cell division; cellular response to DNA damage stimulus; in utero embryonic development; negative regulation by host of viral genome replication; negative regulation of cell cycle arrest; negative regulation of stem cell differentiation; positive regulation of DNA-templated transcription, elongation; positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues; regulation of transcription by RNA polymerase II
Reference #:  O88874 (UniProtKB)
Alt. Names/Synonyms: AW123198; AW413594; Ccnk; CPR4; CycK; cyclin K; Cyclin-K
Gene Symbols: Ccnk
Molecular weight: 61,363 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene