ILK Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; ILK subfamily; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  cell junction; cell-cell junction; costamere; cytosol; dendritic shaft; focal adhesion; lamellipodium; neuronal cell body; nucleoplasm; plasma membrane; protein-containing complex; sarcomere; terminal bouton
Molecular Function:  ATP binding; integrin binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; SH3 domain binding
Biological Process:  branching involved in ureteric bud morphogenesis; cell aging; cell cycle arrest; cell junction assembly; cell proliferation; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelin assembly; myelination in peripheral nervous system; negative regulation of cardiac muscle cell apoptotic process; negative regulation of neural precursor cell proliferation; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; nerve development; neuron projection morphogenesis; outflow tract morphogenesis; peptidyl-serine phosphorylation; positive regulation of axon extension; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of dendrite morphogenesis; positive regulation of MAP kinase activity; positive regulation of myoblast differentiation; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of transcription, DNA-templated; protein heterooligomerization; protein kinase B signaling; protein phosphorylation; regulation of actin cytoskeleton organization; substrate adhesion-dependent cell spreading; supramolecular fiber organization; tumor necrosis factor-mediated signaling pathway
Reference #:  Q13418 (UniProtKB)
Alt. Names/Synonyms: 59 kDa serine/threonine-protein kinase; DKFZp686F1765; epididymis secretory protein Li 28; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; integrin linked kinase; integrin-linked kinase; integrin-linked kinase-2; Integrin-linked protein kinase; P59; p59ILK
Gene Symbols: ILK
Molecular weight: 51,419 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ILK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein