U5-200kD Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Belongs to the helicase family. SKI2 subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2 F1|2 61.84 cM
Cellular Component:  catalytic step 2 spliceosome; nucleoplasm; nucleus; post-mRNA release spliceosomal complex; spliceosomal complex; U4/U6 x U5 tri-snRNP complex; U5 snRNP
Molecular Function:  ATP binding; ATP-dependent helicase activity; ATP-dependent RNA helicase activity; helicase activity; hydrolase activity; identical protein binding; nucleic acid binding; nucleotide binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; RNA splicing; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Reference #:  Q6P4T2 (UniProtKB)
Alt. Names/Synonyms: A330064G03Rik; Activating signal cointegrator 1 complex subunit 3-like 1; Ascc; Ascc3l1; BC011390; BRR2 homolog; HELI; HELIC2; KIAA0788; OTTMUSP00000017113; Small nuclear ribonucleoprotein 200 (U5); small nuclear ribonucleoprotein 200kDa (U5); Snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase; U5 snRNP-specific 200 kDa protein; U5 snRNP-specific protein, 200 kDa; U5 snRNP-specific protein, 200 kDa (DEXH RNA helicase family); U5-200-KD; U5-200KD; U520
Gene Symbols: Snrnp200
Molecular weight: 244,547 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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U5-200kD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene