FNBP3 Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. Belongs to the PRPF40 family. Expressed in the brain cortex (at protein level). Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome
Chromosomal Location of mouse Ortholog: 2|2 C1.1
Cellular Component:  nuclear matrix; nuclear speck; nucleus; U1 snRNP; U2-type prespliceosome
Molecular Function:  proline-rich region binding; protein binding; RNA binding
Biological Process:  cell migration; cytoskeleton organization; mRNA cis splicing, via spliceosome; mRNA processing; mRNA splicing, via spliceosome; regulation of cell shape; regulation of cytokinesis; RNA splicing
Reference #:  Q9R1C7 (UniProtKB)
Alt. Names/Synonyms: 2810012K09Rik; FBP-11; FBP1; Fbp11; Fnb; Fnbp11; Fnbp3; formin binding protein 11; formin binding protein 3; Formin-binding protein 11; Formin-binding protein 3; OTTMUSP00000013317; PR40A; pre-mRNA processing factor 40 homolog A; pre-mRNA processing factor 40A; Pre-mRNA-processing factor 40 homolog A; PRP40 pre-mRNA processing factor 40 homolog A; PRP40 pre-mRNA processing factor 40 homolog A (yeast); Prpf40a; RP23-282A22.2
Gene Symbols: Prpf40a
Molecular weight: 108,481 Da
Basal Isoelectric point: 7.39  Predict pI for various phosphorylation states
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FNBP3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene