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N-CoR1
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Belongs to the N-CoR nuclear receptor corepressors family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 11|11 B2 |
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Cellular Component:
chromatin; cytoplasm; cytosol; histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription regulator complex; transcription repressor complex
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Molecular Function:
chromatin binding; DNA binding; histone deacetylase binding; histone deacetylase regulator activity; nuclear estrogen receptor binding; nuclear receptor binding; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; nuclear thyroid hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription corepressor activity
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Biological Process:
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; cellular response to Thyroglobulin triiodothyronine; cholesterol homeostasis; chromatin organization; circadian regulation of gene expression; definitive erythrocyte differentiation; epidermis development; establishment of skin barrier; gene expression; in utero embryonic development; locomotor rhythm; negative regulation of androgen receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of fatty acid metabolic process; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of JNK cascade; negative regulation of miRNA transcription; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; protein stabilization; regulation of multicellular organism growth; regulation of thyroid hormone mediated signaling pathway; regulation of transcription by RNA polymerase II; rhythmic process; spindle assembly; T cell differentiation in thymus; thalamus development
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Reference #:
Q60974
(UniProtKB)
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Alt. Names/Synonyms: 5730405M06Rik; A230020K14Rik; mKIAA1047; N-CoR; N-CoR1; Ncor1; nuclear receptor co-repressor 1; Nuclear receptor corepressor 1; retinoid X receptor interacting protein 13; Retinoid X receptor-interacting protein 13; RIP13; RP23-330N10.2; Rxr; Rxrip13
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Gene Symbols: Ncor1
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Molecular weight:
270,642 Da
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Basal Isoelectric point:
6.48
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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