LST1 Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. Belongs to the LST1 family. Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 17 B1|17 18.59 cM
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Biological Process:  cell morphogenesis; dendrite development; immune response; immune system process; negative regulation of lymphocyte proliferation; regulation of cell shape
Reference #:  O08843 (UniProtKB)
Alt. Names/Synonyms: B144; leukocyte specific transcript 1; Leukocyte-specific transcript 1 protein; Lst1; Protein B144
Gene Symbols: Lst1
Molecular weight: 10,325 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene