periplakin Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Belongs to the plakin or cytolinker family. Expressed in stratified squamous epithelia and in some other epithelia. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 16 A1|16 2.5 cM
Cellular Component:  cell junction; cytoplasm; cytoskeleton; extrinsic component of plasma membrane; membrane; mitochondrion; nucleus; plasma membrane
Molecular Function:  protein binding; structural molecule activity
Biological Process:  intermediate filament cytoskeleton organization; keratinization; wound healing
Reference #:  Q9R269 (UniProtKB)
Alt. Names/Synonyms: 195kDa protein; AW553870; PEPL; Periplakin; Ppl
Gene Symbols: Ppl
Molecular weight: 204,004 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene