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periplakin
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Belongs to the plakin or cytolinker family. Expressed in stratified squamous epithelia and in some other epithelia. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 16 A1|16 2.5 cM |
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Cellular Component:
anchoring junction; cornified envelope; cytoplasm; cytoskeleton; extrinsic component of plasma membrane; intermediate filament; membrane; plasma membrane
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Molecular Function:
protein binding; structural molecule activity
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Biological Process:
intermediate filament cytoskeleton organization; keratinization; regulation of antibacterial peptide production; wound healing
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Reference #:
Q9R269
(UniProtKB)
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Alt. Names/Synonyms: 195kDa protein; AW553870; PEPL; Periplakin; Ppl
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Gene Symbols: Ppl
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Molecular weight:
204,004 Da
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Basal Isoelectric point:
5.43
Predict pI for various phosphorylation states
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