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Trap170
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: X|X A1.1 |
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Cellular Component:
core mediator complex; mediator complex; nucleus
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Molecular Function:
transcription coactivator activity; transcription coregulator activity
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Biological Process:
positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; stem cell population maintenance; transcription initiation from RNA polymerase II promoter
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Reference #:
A2ABV5
(UniProtKB)
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Alt. Names/Synonyms: 9930001L01Rik; AU041628; Cofactor required for Sp1 transcriptional activation subunit 2; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa); cofactor required for Sp1 transcriptional activation, subunit 2; CRSP complex subunit 2; Crsp2; ENSMUSG00000073278; Gm641; Med14; Mediator complex subunit 14; Mediator of RNA polymerase II transcription subunit 14; ORF1; OTTMUSP00000018469; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170
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Gene Symbols: Med14
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Molecular weight:
160,966 Da
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Basal Isoelectric point:
8.81
Predict pI for various phosphorylation states
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