BUB3 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Belongs to the WD repeat BUB3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 7 F3|7 74.36 cM
Cellular Component:  bub1-bub3 complex; chromosome; chromosome, centromeric region; kinetochore; mitotic checkpoint complex; nucleoplasm; nucleus
Molecular Function:  ubiquitin binding
Biological Process:  attachment of spindle microtubules to kinetochore; cell cycle; cell division; chromosome segregation; meiotic cell cycle; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint; protein localization to kinetochore; regulation of chromosome segregation
Reference #:  Q9WVA3 (UniProtKB)
Alt. Names/Synonyms: AU019800; AU021329; AU043350; AW146323; Bub3; BUB3 mitotic checkpoint protein; budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae); C78067; Mitotic checkpoint protein BUB3; WD repeat type I transmembrane protein A72.5
Gene Symbols: Bub3
Molecular weight: 36,955 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene