PGRMC1 Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Belongs to the cytochrome b5 family. MAPR subfamily. Widely expressed, with highest expression in liver and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: X|X A3.3
Cellular Component:  cell body; endoplasmic reticulum; integral component of membrane; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; synapse
Molecular Function:  lipid binding; steroid binding
Biological Process:  associative learning; memory; modification of synaptic structure; negative regulation of synapse organization; positive regulation of protein localization to plasma membrane
Reference #:  O55022 (UniProtKB)
Alt. Names/Synonyms: AA415812; HPR6.6; Membrane-associated progesterone receptor component 1; OTTMUSP00000018583; PGRC1; Pgrmc; Pgrmc1; PPMR; progesterone receptor membrane component 1; Vema
Gene Symbols: Pgrmc1
Molecular weight: 21,694 Da
Basal Isoelectric point: 4.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PGRMC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene