MYO1C Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Contractile; Lipid-binding; Motility/polarity/chemotaxis; Motor; Nucleolus
Chromosomal Location of Human Ortholog: 11 B5|11 45.92 cM
Cellular Component:  basal plasma membrane; brush border; cell projection; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; filamentous actin; lateral plasma membrane; membrane; membrane raft; microvillus; myosin complex; nuclear body; nuclear pore; nucleus; phagocytic vesicle; plasma membrane; ruffle membrane; stereocilium; stereocilium bundle
Molecular Function:  actin binding; actin filament binding; actin-dependent ATPase activity; ATP binding; calmodulin binding; microfilament motor activity; motor activity; nucleotide binding; phospholipid binding; protein binding; protein C-terminus binding; Ral GTPase binding; signaling receptor binding
Biological Process:  cellular response to interferon-gamma; mRNA transport; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of cellular response to insulin stimulus; positive regulation of protein targeting to membrane; positive regulation of vascular endothelial growth factor signaling pathway; protein targeting; protein targeting to membrane; protein transport; regulation of bicellular tight junction assembly; vesicle transport along actin filament
Reference #:  Q9WTI7 (UniProtKB)
Alt. Names/Synonyms: C80397; mm1beta; MMI-beta; MMIb; Myo1c; MYO1E; Myosin I beta; myosin IC; myosin-Ibeta; Myosin-Ic; myr2; NMI; nuclear myosin I beta; OTTMUSP00000006508; OTTMUSP00000006510; OTTMUSP00000006511; Unconventional myosin-Ic
Gene Symbols: Myo1c
Molecular weight: 121,944 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene