QIK Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily
Chromosomal Location of Human Ortholog: 9|9 A5.3
Cellular Component:  cytoplasm; nucleotide-activated protein kinase complex; nucleus
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to glucose starvation; insulin receptor signaling pathway; intracellular signal transduction; negative regulation of TOR signaling; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of insulin receptor signaling pathway
Reference #:  Q8CFH6 (UniProtKB)
Alt. Names/Synonyms: G630080D20Rik; QIK; salt induceable kinase 2; salt inducible kinase 2; Salt-inducible kinase 2; Salt-inducible protein kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; Sik2; Snf1; SNF1-like kinase 2; Snf1lk2
Gene Symbols: Sik2
Molecular weight: 104,198 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein