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QIK
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily |
| Chromosomal Location of mouse Ortholog: 9|9 A5.3 |
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Cellular Component:
cytoplasm; endoplasmic reticulum membrane; nucleus
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Molecular Function:
ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
insulin receptor signaling pathway; intracellular signal transduction; negative regulation of glycolytic process; negative regulation of lipid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter by glucose; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of insulin receptor signaling pathway
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Reference #:
Q8CFH6
(UniProtKB)
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Alt. Names/Synonyms: G630080D20Rik; QIK; salt induceable kinase 2; salt inducible kinase 2; Salt-inducible kinase 2; Salt-inducible protein kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; Sik2; Snf1; SNF1-like kinase 2; Snf1lk2
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Gene Symbols: Sik2
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Molecular weight:
104,198 Da
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Basal Isoelectric point:
5.76
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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