GRIP1 May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q22
Cellular Component:  cell junction; dendrite; endoplasmic reticulum membrane; glutamatergic synapse; membrane raft; neuron projection; neuronal cell body; plasma membrane; postsynapse; postsynaptic density; postsynaptic membrane; recycling endosome
Molecular Function:  glucocorticoid receptor binding; protein binding; protein C-terminus binding; receptor signaling complex scaffold activity; signaling receptor binding
Biological Process:  dendrite development; nervous system development; neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of neuron projection arborization; positive regulation of signal transduction; protein localization; protein transport; vesicle-mediated transport in synapse
Reference #:  P97879 (UniProtKB)
Alt. Names/Synonyms: AMPA receptor-interacting protein GRIP1; glutamate receptor interacting protein 1; Glutamate receptor-interacting protein 1; GRIP-1; Grip1
Gene Symbols: Grip1
Molecular weight: 120,298 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below

GRIP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene