GRIP1 a scaffold protein for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific locations in neurons. Interacts with EphA7, EphB2, KIF5A, -B, -C, GluR2, -3, GRIPAP1, liprin A1, PPFIA4, FRAS1, and PTPRF. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q22
Cellular Component:  cell junction; dendrite; endoplasmic reticulum membrane; glutamatergic synapse; membrane raft; neuron projection; neuronal cell body; plasma membrane; postsynapse; postsynaptic density; postsynaptic membrane; recycling endosome
Molecular Function:  glucocorticoid receptor binding; protein binding; protein C-terminus binding; receptor signaling complex scaffold activity; signaling receptor binding
Biological Process:  dendrite development; nervous system development; neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of neuron projection arborization; positive regulation of signal transduction; protein localization; protein transport; vesicle-mediated transport in synapse
Reference #:  P97879 (UniProtKB)
Alt. Names/Synonyms: AMPA receptor-interacting protein GRIP1; glutamate receptor interacting protein 1; Glutamate receptor-interacting protein 1; GRIP-1; Grip1
Gene Symbols: Grip1
Molecular weight: 120,298 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene