LMO6 Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation. PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module. Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions. Involved in the organization of the basal body. Involved in cilia growth and positioning. Belongs to the prickle / espinas / testin family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component:  centrosome; cytoplasm; nucleus; plasma membrane
Molecular Function:  protein binding; zinc ion binding
Biological Process:  cell projection organization; multicellular organism development
Disease: Leber Hereditary Optic Neuropathy, Modifier Of
Reference #:  O43900 (UniProtKB)
Alt. Names/Synonyms: LIM domain only protein 6; LMO-6; LMO6; Pk3; PRIC3; prickle homolog 3; prickle homolog 3 (Drosophila); Prickle planar cell polarity protein 3; Prickle-like protein 3; PRICKLE3; Triple LIM domain protein 6
Gene Symbols: PRICKLE3
Molecular weight: 68,609 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene