TIAL1 RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  cytoplasm; cytoplasmic stress granule; nucleus; ribonucleoprotein complex
Molecular Function:  DNA binding; mRNA 3'-UTR AU-rich region binding; nucleic acid binding; protein binding; RNA binding
Biological Process:  apoptotic process; germ cell development; positive regulation of cell proliferation; stem cell division
Reference #:  P70318 (UniProtKB)
Alt. Names/Synonyms: 5330433G13Rik; AL033329; mTIAR; Nucleolysin TIAR; OTTMUSP00000030897; TIA-1-related protein; Tia1 cytotoxic granule-associated RNA binding protein-like 1; Tial1; Tial1 cytotoxic granule-associated RNA binding protein-like 1; Tial1 cytotoxic granule-associated RNA-binding protein-like 1; TIAR
Gene Symbols: Tial1
Molecular weight: 43,389 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene