eIF4G Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. 8 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of mouse Ortholog: 16|16 B1
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; nucleus; polysome; postsynapse
Molecular Function:  ATP binding; eukaryotic initiation factor 4E binding; identical protein binding; mRNA binding; protein binding; RNA binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  behavioral fear response; cellular macromolecule biosynthetic process; cellular response to nutrient levels; energy homeostasis; mitochondrion organization; negative regulation of autophagy; negative regulation of peptidyl-threonine phosphorylation; positive regulation of cell death; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of eukaryotic translation initiation factor 4F complex assembly; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of miRNA mediated inhibition of translation; positive regulation of mRNA cap binding; positive regulation of neuron differentiation; positive regulation of peptidyl-serine phosphorylation; regulation of polysome binding; regulation of presynapse assembly; regulation of translational initiation; translation
Reference #:  Q6NZJ6 (UniProtKB)
Alt. Names/Synonyms: E030015G23Rik; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; eIF4G; Eif4g1; eIF4GI; Eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4, gamma 1; IF4G1; MGC37551; MGC90776; OTTMUSP00000029085; OTTMUSP00000029549
Gene Symbols: Eif4g1
Molecular weight: 176,077 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene