RBM14 Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; nuclear speck; nucleus; transcription factor complex
Molecular Function:  nuclear receptor transcription coactivator activity; nucleic acid binding; RNA binding
Biological Process:  activation of innate immune response; centriole assembly; histone deacetylation; immune system process; innate immune response; negative regulation of centriole replication; positive regulation of transcription by RNA polymerase II; SMAD protein signal transduction
Reference #:  Q8C2Q3 (UniProtKB)
Alt. Names/Synonyms: 1300007E16Rik; p16; p16K; PSP2; Rbm14; RNA binding motif protein 14; RNA-binding motif protein 14; RNA-binding protein 14; synaptotagmin interacting protein; Sytip
Gene Symbols: Rbm14
Molecular weight: 69,449 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA