FOP Required for anchoring microtubules to the centrosomes. Required for ciliation. Belongs to the FGFR1OP family. Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17|17 A1
Cellular Component:  cell projection; centrosome; cytoplasm; cytoskeleton; microtubule organizing center; nucleus; perinuclear region of cytoplasm
Molecular Function:  protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity
Biological Process:  cell projection organization; microtubule anchoring; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation
Reference #:  Q66JX5 (UniProtKB)
Alt. Names/Synonyms: 4930553O10Rik; Centrosomal protein 43; CEP43; Fgfr; FGFR1 oncogene partner; Fgfr1op; FOP; FR1OP; MGC117820; MGC90966
Gene Symbols: Fgfr1op
Molecular weight: 42,758 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
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FOP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene