ZNF516 a transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress. Belongs to the krueppel C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription regulation
Chromosomal Location of Human Ortholog: 18q23
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; proximal promoter sequence-specific DNA binding
Biological Process:  adipose tissue development; brown fat cell differentiation; positive regulation of cold-induced thermogenesis; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; response to cold
Reference #:  Q92618 (UniProtKB)
Alt. Names/Synonyms: HsT287; KIAA0222; Zinc finger protein 516; ZN516; ZNF516
Gene Symbols: ZNF516
Molecular weight: 124,289 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB