CHD-3 iso3 Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Belongs to the SNF2/RAD54 helicase family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.12; Helicase
Chromosomal Location of human Ortholog: 17p13.1
Cellular Component:  centrosome; cytoplasm; microtubule organizing center; nucleolus; nucleoplasm; nucleus; NuRD complex
Molecular Function:  ATP binding; ATP-dependent DNA helicase activity; ATPase activity; DNA binding; double-stranded DNA-dependent ATPase activity; helicase activity; nucleosome-dependent ATPase activity; protein binding; zinc ion binding
Biological Process:  ATP-dependent chromatin remodeling; centrosome cycle; chromatin assembly or disassembly; DNA duplex unwinding; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; spindle organization
Disease: Snijders Blok-campeau Syndrome
Reference #:  Q12873-3 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD3; CHD-3; CHD-3 iso3; CHD3; chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3; hZFH; Mi-2 autoantigen 240 kDa protein; Mi-2a; Mi2-alpha; SNIBCPS; ZFH; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Symbols: CHD3
Molecular weight: 233,037 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CHD-3 iso3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene