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CHD-3 iso3
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Belongs to the SNF2/RAD54 helicase family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 3.6.4.12; Helicase |
| Chromosomal Location of human Ortholog: 17p13.1 |
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Cellular Component:
centriolar satellite; centrosome; chromatin; cytoplasm; nucleolus; nucleoplasm; nucleus; NuRD complex; PML body
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; chromatin binding; DNA binding; helicase activity; histone binding; protein binding; transcription cis-regulatory region binding; zinc ion binding
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Biological Process:
centrosome cycle; chromatin remodeling; histone deacetylation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of cell fate specification; regulation of DNA-templated transcription; regulation of stem cell differentiation; spindle organization
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Disease: Snijders Blok-campeau Syndrome
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Reference #:
Q12873-3
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent helicase CHD3; CHD-3; CHD-3 iso3; CHD3; chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3; hZFH; Mi-2 autoantigen 240 kDa protein; Mi-2a; Mi2-alpha; SNIBCPS; ZFH; Zinc finger helicase; zinc-finger helicase (Snf2-like)
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Gene Symbols: CHD3
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Molecular weight:
233,037 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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