AHNAK a giant propeller-like protein that associates with calcium channel proteins of cardiomyocytes and other cells. Translocates from the cytosol to the plasma membrane during the formation of cell-cell contacts and the development of epithelial polarity. At the plasma membrane, it associates as a multimeric complex with actin and the annexin 2/S100A10 complex. The AHNAK/annexin 2/S100A10 complex regulates cortical actin cytoskeleton organization and the architecture of the cell membrane. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cytoskeletal
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  actin cytoskeleton; cell-cell contact zone; costamere; cytoplasm; cytosol; extracellular exosome; nucleus; plasma membrane; sarcolemma; T-tubule; vesicle
Molecular Function:  protein binding; S100 protein binding; structural molecule activity conferring elasticity
Biological Process:  protein complex oligomerization; regulation of RNA splicing; regulation of voltage-gated calcium channel activity
Reference #:  Q09666 (UniProtKB)
Alt. Names/Synonyms: AHNAK; AHNAK nucleoprotein; AHNAK-related; AHNAKRS; AHNK; Desmoyokin; MGC5395; Neuroblast differentiation-associated protein AHNAK; PM227
Gene Symbols: AHNAK
Molecular weight: 629,101 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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