AHNAK a giant propeller-like protein that associates with calcium channel proteins of cardiomyocytes and other cells. Translocates from the cytosol to the plasma membrane during the formation of cell-cell contacts and the development of epithelial polarity. At the plasma membrane, it associates as a multimeric complex with actin and the annexin 2/S100A10 complex. The AHNAK/annexin 2/S100A10 complex regulates cortical actin cytoskeleton organization and the architecture of the cell membrane. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cytoskeletal
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  actin cytoskeleton; cell-cell contact zone; costamere; cytoplasm; cytosol; extracellular exosome; membrane raft; nucleus; plasma membrane; sarcolemma; T-tubule; vesicle
Molecular Function:  protein binding; S100 protein binding
Biological Process:  protein oligomerization; regulation of RNA splicing; regulation of voltage-gated calcium channel activity
Reference #:  Q09666 (UniProtKB)
Alt. Names/Synonyms: AHNAK; AHNAK nucleoprotein; AHNAK-related; AHNAKRS; AHNK; Desmoyokin; MGC5395; Neuroblast differentiation-associated protein AHNAK; PM227
Gene Symbols: AHNAK
Molecular weight: 629,101 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Select Structure to View Below

AHNAK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein