USP19 Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Belongs to the peptidase C19 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Membrane protein, integral; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  cytosol; endoplasmic reticulum membrane
Molecular Function:  cysteine-type deubiquitinase activity; Hsp90 protein binding; metal ion binding; protein binding
Biological Process:  negative regulation of skeletal muscle tissue development; positive regulation of cell cycle process; protein deubiquitination; protein stabilization; regulation of cellular response to hypoxia; regulation of ERAD pathway; regulation of protein stability; response to endoplasmic reticulum stress; ubiquitin-dependent ERAD pathway
Reference #:  O94966 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 19; KIAA0891; Ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific peptidase 19; ubiquitin specific protease 19; Ubiquitin thioesterase 19; ubiquitin thiolesterase 19; Ubiquitin-specific-processing protease 19; UBP19; USP19; Zinc finger MYND domain-containing protein 9; ZMYND9
Gene Symbols: USP19
Molecular weight: 145,651 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
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USP19

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein