USP19
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Belongs to the peptidase C19 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.19.12; Membrane protein, integral; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
Chromosomal Location of human Ortholog: 3p21.31 |
Cellular Component:
cytosol; endoplasmic reticulum membrane
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Molecular Function:
cysteine-type deubiquitinase activity; Hsp90 protein binding; metal ion binding; protein binding
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Biological Process:
negative regulation of skeletal muscle tissue development; positive regulation of cell cycle process; protein deubiquitination; protein stabilization; regulation of cellular response to hypoxia; regulation of ERAD pathway; regulation of protein stability; response to endoplasmic reticulum stress; ubiquitin-dependent ERAD pathway
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Reference #:
O94966
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme 19; KIAA0891; Ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific peptidase 19; ubiquitin specific protease 19; Ubiquitin thioesterase 19; ubiquitin thiolesterase 19; Ubiquitin-specific-processing protease 19; UBP19; USP19; Zinc finger MYND domain-containing protein 9; ZMYND9
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Gene Symbols: USP19
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Molecular weight:
145,651 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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