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SRC-3
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Belongs to the SRC/p160 nuclear receptor coactivator family. Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
disordered domain specific binding; histone acetyltransferase activity; molecular adaptor activity; nuclear receptor binding; nuclear receptor coactivator activity; nuclear thyroid hormone receptor binding; protein binding; protein dimerization activity; RNA polymerase II complex binding; transcription coactivator activity
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Biological Process:
cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; chromatin remodeling; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; receptor transactivation; regulation of stem cell division
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Reference #:
Q9Y6Q9
(UniProtKB)
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Alt. Names/Synonyms: ACTR; AIB-1; AIB1; Amplified in breast cancer 1 protein; BHLHE42; CAGH16; CBP-interacting protein; Class E basic helix-loop-helix protein 42; CTG26; KAT13B; MGC141848; NCoA-3; NCOA3; Nuclear receptor coactivator 3; pCIP; RAC-3; RAC3; Receptor-associated coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1; TRAM1
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Gene Symbols: NCOA3
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Molecular weight:
155,293 Da
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Basal Isoelectric point:
7.16
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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