GCFC Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. Belongs to the GCF family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Spliceosome; Transcription factor
Chromosomal Location of human Ortholog: 21q22.11
Cellular Component: 
Molecular Function:  DNA-binding transcription factor activity; transcription factor binding
Biological Process:  muscle organ development; positive regulation of histone methylation; positive regulation of myoblast proliferation; regulation of skeletal muscle satellite cell proliferation
Reference #:  Q9Y5B6 (UniProtKB)
Alt. Names/Synonyms: BM020; C21orf66; FSAP105; functional spliceosome-associated protein 105; GC-rich sequence DNA-binding factor 1; GC-rich sequence DNA-binding factor candidate; GC-rich sequence DNA-binding factor homolog; GCFC; GCFC1; PAX3 and PAX7 binding protein 1; PAX3- and PAX7-binding protein 1; PAXB1; PAXBP1
Gene Symbols: PAXBP1
Molecular weight: 104,804 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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GCFC

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein