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GRK2
a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; BARK subfamily; EC 2.7.11.15; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of Human Ortholog: 11q13.2 |
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Cellular Component:
cilium; cytoplasm; cytosol; membrane; plasma membrane
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Molecular Function:
alpha-2A adrenergic receptor binding; ATP binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; G protein-coupled receptor kinase activity; protein binding; protein kinase activity
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Biological Process:
cardiac muscle contraction; desensitization of G protein-coupled receptor signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; heart development; negative regulation of striated muscle contraction; negative regulation of the force of heart contraction by chemical signal; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of catecholamine secretion; receptor internalization; tachykinin receptor signaling pathway; viral entry into host cell; viral genome replication
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Reference #:
P25098
(UniProtKB)
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Alt. Names/Synonyms: ADRBK1; adrenergic, beta, receptor kinase 1; ARBK1; BARK; BARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; BETA-ARK1; FLJ16718; G-protein coupled receptor kinase 2; GRK2
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Gene Symbols: GRK2
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Molecular weight:
79,574 Da
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Basal Isoelectric point:
6.89
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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