IRS2 May mediate the control of various cellular processes by insulin. Interacts with PHIP. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component:  cytosol; plasma membrane; protein-containing complex
Molecular Function:  14-3-3 protein binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding
Biological Process:  axon guidance; brain development; cell proliferation; cellular response to glucose stimulus; cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; interleukin-7-mediated signaling pathway; lipid homeostasis; mammary gland development; MAPK cascade; negative regulation of B cell apoptotic process; negative regulation of kinase activity; negative regulation of plasma membrane long-chain fatty acid transport; phosphatidylinositol-mediated signaling; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; positive regulation of mesenchymal cell proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of Ras protein signal transduction; regulation of lipid metabolic process; response to glucose; signal transduction
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  Q9Y4H2 (UniProtKB)
Alt. Names/Synonyms: Insulin receptor substrate 2; IRS-2; IRS2
Gene Symbols: IRS2
Molecular weight: 137,334 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IRS2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene