SMC3 Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Belongs to the SMC family. SMC3 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of human Ortholog: 10q25.2
Cellular Component:  chromatin; chromosome; chromosome, centromeric region; cohesin complex; cytosol; lateral element; meiotic cohesin complex; mitotic cohesin complex; mitotic spindle pole; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; beta-tubulin binding; chromatin binding; cohesin loading activity; double-stranded DNA binding; dynein complex binding; mediator complex binding; microtubule motor activity; protein binding; protein heterodimerization activity
Biological Process:  cell division; DNA repair; establishment of meiotic sister chromatid cohesion; establishment of mitotic sister chromatid cohesion; meiotic cell cycle; mitotic cell cycle; mitotic sister chromatid cohesion; mitotic spindle assembly; regulation of DNA replication; sister chromatid cohesion; stem cell population maintenance
Disease: Cornelia De Lange Syndrome 3
Reference #:  Q9UQE7 (UniProtKB)
Alt. Names/Synonyms: BAM; Bamacan; Basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; Chondroitin sulfate proteoglycan 6; chondroitin sulfate proteoglycan 6 (bamacan); Chromosome-associated polypeptide; CSPG6; hCAP; SMC protein 3; SMC-3; SMC3; SMC3L1; structural maintenance of chromosomes 3; Structural maintenance of chromosomes protein 3
Gene Symbols: SMC3
Molecular weight: 141,542 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SMC3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene