NSFL1C Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 20p13
Cellular Component:  chromosome; cytosol; Golgi stack; intermediate filament cytoskeleton; nucleoplasm; plasma membrane; spindle pole centrosome; VCP-NSFL1C complex
Molecular Function:  ATPase binding; phospholipid binding; protein binding
Biological Process:  establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; positive regulation of mitotic centrosome separation
Reference #:  Q9UNZ2 (UniProtKB)
Alt. Names/Synonyms: dJ776F14.1; MGC3347; NSF1C; NSFL1 (p97) cofactor (p47); NSFL1 cofactor; NSFL1 cofactor p47; NSFL1C; p47; p97 cofactor p47; SHP1 homolog; UBX domain protein 2C; UBX domain-containing protein 2C; UBX1; UBXD10; UBXN2C
Gene Symbols: NSFL1C
Molecular weight: 40,573 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein