TPX2 Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Belongs to the TPX2 family. Expressed in lung carcinoma cell lines but not in normal lung tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component:  axon hillock; cytosol; intercellular bridge; microtubule; microtubule cytoskeleton; microtubule organizing center; mitotic spindle; nucleoplasm; nucleus; spindle
Molecular Function:  importin-alpha family protein binding; protein binding; protein kinase binding
Biological Process:  activation of protein kinase activity; apoptotic process; cell division; mitotic cell cycle; mitotic spindle assembly; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic spindle organization; regulation of signal transduction by p53 class mediator
Reference #:  Q9ULW0 (UniProtKB)
Alt. Names/Synonyms: C20orf1; C20orf2; Differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; Hepatocellular carcinoma-associated antigen 519; p100; preferentially expressed in colorectal cancer; Protein fls353; REPP86; restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; Targeting protein for Xklp2; TPX2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog (Xenopus laevis)
Gene Symbols: TPX2
Molecular weight: 85,653 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TPX2

Protein Structure Not Found.


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